Stem cells

Stem cells are the body's raw materials and are the cells from which all other cells with special functions originate. Under the right conditions in the body or in the laboratory, stem cells divide to create more cells called daughter cells. These daughter cells differentiate into either new stem cells or specialized cells with a more specific function, such as blood cells, brain cells, heart muscle cells, or bone cells. Types of stem cells include hematopoietic stem cell, embryonic stem cell, and mesenchymal stem cell.

Extracellular vesicles/Exosome

Extracellular vesicles/Exosomes are small nano-sized extracellular vesicles secreted by many different cells that carry nucleic acids, growth factors, proteins, lipids, amino acids and other bioactive substances to play a role in the body's physiological and pathological processes. Exosomes, which contain trace amounts of genetic material and cell debris, cause a low level of immune response. While exosomes can be obtained from animal sources in biological fluids such as serum, plasma, cerebrospinal fluid, and all body cells, they can also be obtained from plant cells and used for therapeutic purposes.

PRP/PRF

Platelet rich plasma (PRP) is a simple, effective and minimally invasive method to naturally obtain a high concentration of autologous growth factors. The production of PRP, which contains a high concentration of platelets, involves centrifuging autologous blood to separate and remove the plasma and buffy coat portion of the whole blood. PRP offers usage in different fields such as dentistry, dermatology, plastic and maxillofacial surgery, acute trauma and plastic surgery. The main reason for the widespread use of PRP in the treatment of diseases with different pathophysiological mechanisms is that it contains important growth factors and other signaling molecules, including the presence of platelets and various blood cells, leukocyte-derived catabolic cytokines and fibrinogen, which can support and regulate the tissue repair process.

Platelet-rich fibrin (PRF); the structure, known as the second-generation platelet concentrate, is rich in autologous platelets and leukocytes that aim to accumulate platelets, immune modulators and inflammatory cytokines within the fibrin clot. Since the PRF preparation protocol is simple and effective and does not require any anticoagulant, the wound healing process due to the use of PRF is not prevented by anticoagulants and coagulation occurs naturally. PRF has several advantages, including a high concentration of leukocytes that not only play a role in immune and antibacterial responses but also support the wound healing process. PRF spontaneously forms a dense fibrin network, allowing the rate of degradation to slow down and thus delaying the release of growth factors into the surrounding tissue during wound healing.

SVF

Stromal Vascular Fraction (SVF) is the common product obtained during the processing of adipose tissue. SVF, derived by breaking down adipose tissue by enzymatic or mechanical methods, does not contain mature adipocytes but consists of a heterogeneous cell mixture including adipose tissue stem cells, adipose tissue progenitor cells, fibroblasts, immune cells, epithelial cells, endothelial cells and other cell types associated with the circulatory and nervous systems. occurs. SVF treatment; It is an advanced approach in cellular therapy used in patients with various autoimmune, urological, neurological, pulmonary, ophthalmological and orthopedic diseases. SVF contains several different types of stem cells as well as growth factors and other biologically active components. Isolation of SVF cells from adipose tissue is a very simple process. The entire process, including pre-anesthesia, isolation, and injection of SVF cells, takes only approximately 4 hours and can be performed in a clinic, requiring no laboratory.

Research and development activities include the discovery and production of products such as stem cells, extracellular vesicles, exosomes and SVF.